Dosage and Administration
iAluRil treatment begins with a course of instillations given once a week for the first month.
The recommended dosage is then*:
one instillation every two weeks for the second month. In the following months, one instillation a month should be given until symptoms resolve to the satisfaction of both the clinician and patient.
From clinical trials, data has shown that further instillations can then be given at varying intervals dependent on the condition being treated:7
Painful Bladder Syndrome/ Interstitial Cystitis: at weeks 6 and 8.
Prevention of Urinary Tract Infections: monthly for 5 months.
Chemical induced cystitis (Including BCG): weekly for another 4 weeks.
Radiation induced cystitis: at weeks 6, 8 and 12.
Once the symptoms have improved, the interval between instillations can be increased slowly until you are happy that the regular doses are enough to keep symptoms under control. If the symptoms reoccur, the initial course of instillations can be repeated in order to settle the symptoms down again.
|Clinical efficacy Protocols|
|Condition||Number of instillations||Administration regimen||Referred clinical work|
|Recurrent Urinary Tract Infection (rUTI)||9||Weekly for 4 weeks, then monthly for 5 months||Damiano et al 20111, Cicione et al. 20142|
|Painful Bladder Syndrome/ Interstitial Cystitis (PBS / IC)||6||Weekly for 4 weeks, then at weeks 6 and 8*||iAluRil Prefill patient leaflet|
|Chemical induced Cystitis (including BCG)||8||weekly for 8 weeks||Imperatore et al. 20183, Creta et al. 20124|
|Radiation induced cystitis||7||Weekly for 4 weeks, then at weeks 6, 8 and 12||Gacci et al. 20165, Giannessi et al. 20146|
Method of administration
iAluRil is administered intravesically as a 50 ml bladder instillation via catheter (with Luer-Lock adapter) or using the ialuadapter®.
Administration via the catheter
- After the patient has urinated spontaneously, empty the bladder of all traces of urine by inserting a suitable sterile catheter through the external urethral meatus and wait for all the urine in the bladder to be evacuated (use of an 8 Ch catheter is recommended during this stage).
- Screw the plunger rod supplied with the prefilled syringe, until it is perfectly in place.
- Mount the Luer-Lock adapter on the top of the prefilled syringe and apply onto it the sterile catheter previously placed in the bladder.
- Instill all the solution contained in the syringe into the bladder through the catheter.
- Keep iAluRil in the bladder for as long as possible (minimum time recommended is 30 minutes).
Administration via the iAluadapter®
1. The patient urinates spontaneously.
2. Screw the plunger rod supplied with the prefilled syringe, until it is perfectly in place.
3. Fasten the iAluadapter® to the top of the prefilled syringe.
4. Instill all the solution contained in the syringe into the bladder through the iAluadapter®.
5. Keep iAluRil in the bladder for as long as possible (minimum time recommended is 30 minutes).
The iAluadapter® is an innovative device for catheter-free administration of iAluRil.®
Catheter-free GAG therapy
• Minimally invasive and practically pain free
• Enables simultaneous treatment of the urethral and bladder mucosa
• Low risk of infection
• Included in iAluRil® packs at no extra cost
Only licensed for use with iAluRil®
DEPENDABLE SUPPLY CHAIN.
For further information please call: 01730 231148,
email: firstname.lastname@example.org or visit www.aspirepharma.co.uk